An Updated Review on Memantine Efficacy in Reducing Cognitive Dysfunction of Whole-brain Irradiation for Adult Patients with Brain metastasis

Context: Increased survival of patients with cancer raises the need to pay attention long-term side effects. Patients brain metastasis experienced cognition failure after whole-brain radiotherapy. This review aimed at concluding efficacy Memantine in preserving cognitive function by reducing toxicity radiotherapy for metastatic cancers. Evidence Acquisition: Published studies evaluating memantine protective effects during were searched scientific databases (e.g., Embase, PubMed, Cochrane database, Google Scholar, Scopus) using keywords including and Memantine. Results: A total 4 prospective clinical trials included review. Effects on tests evaluated these trials. significantly better Hopkins Verbal Learning Test-Revised (HVLT-R) delayed recognition months 6 was achieved RTOG 0614 NRG CC001. Longer time decline found arm trial statistically significant. not significant before 2 months. Conclusions: It seems reasonable consider radiation prevent due current results. improves (WBRT) without adding irreparable complications.